CAS No. 1630086-20-2

Batch: Purity:99.85
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Kira8 Chemical Structure
Chemical Structure
Check the Kira8 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-chloro-N-[6-methyl-5-[[3-[2-[[(3S)-piperidin-3-yl]amino]pyrimidin-4-yl]-2-pyridinyl]oxy]naphthalen-1-yl]benzenesulfonamide
CAS Number 1630086-20-2
Molecular Formula

C31H29ClN6O3S
Molecular Weight (MW) 601.12
SMILES CC1=C(OC2=C(C=CC=N2)C3=NC(=NC=C3)NC4CCCNC4)C5=C(C=C1)C(=CC=C5)N[S;v6](=O)(=O)C6=C(Cl)C=CC=C6
InChIKey XMWUCMFVDXDRDE-NRFANRHFSA-N

Ordering Information

Biological Activity

Kira8 is a monoselective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity. By targeting the IRE1α branch of the unfolded protein response (UPR), Kira8 suppresses downstream XBP1 mRNA splicing and attenuates endoplasmic reticulum stress-induced apoptosis. In preclinical models, this inhibition blocks terminal UPR signaling and spares pancreatic β-cells, restoring homeostatic signaling during chronic cellular stress. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (166.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.