CAS No. 1589527-65-0

Batch: Purity:99.94
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kira6 Chemical Structure
Chemical Structure
Check the kira6 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[4-(8-amino-3-tert-butylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl]-3-[3-(trifluoromethyl)phenyl]urea
CAS Number 1589527-65-0
Molecular Formula

C28H25F3N6O
Molecular Weight (MW) 518.53
SMILES CC(C)(C)C1=NC(=C2N1C=CN=C2N)C3=CC=C(C4=CC=CC=C43)NC(=O)NC5=CC=CC(=C5)C(F)(F)F
InChIKey NOHQEAFAESMMDX-UHFFFAOYSA-N

Ordering Information

Biological Activity

KIRA6 is a potent, type II IRE1α kinase inhibitor with an IC50 offor IRE1α kinase activity. By allosterically inhibiting IRE1α kinase and endoribonuclease domains, it suppresses IRE1α oligomerization as well as XBP1 and Ins2 RNA cleavage. This block in unfolded protein response (UPR) signaling reduces ER stress-induced apoptosis and preserves cellular viability. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 60 mg/mL (115.71 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 60 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.