CAS No. 1799974-70-1

Batch: Purity:99.70
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KI696 Chemical Structure
Chemical Structure
Check the KI696 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S)-3-(7-methoxy-1-methylbenzotriazol-5-yl)-3-[4-methyl-3-[[(4R)-4-methyl-1,1-dioxo-3,4-dihydro-5,1λ6,2-benzoxathiazepin-2-yl]methyl]phenyl]propanoic acid
CAS Number 1799974-70-1
Molecular Formula

C28H30N4O6S
Molecular Weight (MW) 550.63
InChIKey ZDNGJXBUEQNFBQ-GCJKJVERSA-N

Biological Activity

is a potent and selective inhibitor of the KEAP1/NRF2 protein-protein interaction. By disrupting the binding of KEAP1 to NRF2, KI696 prevents KEAP1-mediated degradation of NRF2, leading to NRF2 accumulation and nuclear translocation. This activation upregulates downstream antioxidant genes including Nqo1, Ho-1, Txnrd1, Srxn1, Gsta, and Gclc in a dose-dependent manner to enhance cytoprotective cellular defenses against oxidative stress. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (181.61 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Davies TG, et al. J Med Chem. 2016;59(8):3991-4006.

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Note: Technical data last updated: Sep 1, 2026.