CAS No. 1784282-12-7
Chemical Information
| IUPAC Name | 4-N-(2-methylpropyl)-2-N-[(2-phenyl-1,3-thiazol-4-yl)methyl]pyrimidine-2,4-diamine;hydrochloride | |
|---|---|---|
| CAS Number | 1784282-12-7 | |
| Molecular Formula |
C18H22ClN5S |
|
| Molecular Weight (MW) | 375.92 | |
| SMILES | CC(C)CNC1=NC(=NC=C1)NCC2=CSC(=N2)C3=CC=CC=C3.Cl | |
| InChIKey | INVQHPQJFRKGIO-UHFFFAOYSA-N |
Biological Activity
KHS101 hydrochloride is a small-molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3), a regulator of centrosome-microtubule dynamic networks. By disrupting TACC3 interaction and interfering with mitochondrial chaperone networks, KHS101 selectively impairs glioblastoma cell self-renewal, suppresses tumor proliferation, and induces apoptotic cell death. Furthermore, KHS101 disrupts metabolic homeostasis in glioblastoma stem cells, providing a targetable vulnerability in high-grade brain tumors. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
| Solvent | Solubility & Note |
|---|---|
| DMSO |
59 mg/mL
(156.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 59 mg/mL |
| Water | Insoluble |
| DMSO |
75 mg/mL
(199.51 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 57 mg/mL |
| Water | 3 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
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