CAS No. 666842-36-0
Batch:
Purity:99.75
Chemical Structure
Check the
KGA-2727
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[3-[3-methyl-4-[[5-propan-2-yl-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1H-pyrazol-4-yl]methyl]phenoxy]propylamino]propanamide | |
|---|---|---|
| CAS Number | 666842-36-0 | |
| Molecular Formula |
C26H40N4O8 |
|
| Molecular Weight (MW) | 536.62 | |
| SMILES | CC1=C(C=CC(=C1)OCCCNCCC(=O)N)CC2=C(NN=C2OC3C(C(C(C(O3)CO)O)O)O)C(C)C | |
| InChIKey | MDBARDSTXONTFS-MNDUUMEHSA-N |
KGA-2727 is a potent, selective inhibitor of human SGLT1 (Ki 97.4 nM) and rat SGLT1 (Ki 43.5 nM), exhibiting 140-fold and 390-fold selectivity over human and rat SGLT2, respectively. By inhibiting renal and intestinal SGLT1-mediated glucose transport, KGA-2727 delays intestinal glucose absorption and enhances urinary glucose excretion, ultimately improving postprandial hyperglycemia and demonstrating antidiabetic efficacy in rodent models.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(186.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 45 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.