CAS No. 18228-17-6
Batch:
Purity:99.81
Chemical Structure
Check the
KG-501
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [3-[(4-chlorophenyl)carbamoyl]naphthalen-2-yl] dihydrogen phosphate | |
|---|---|---|
| CAS Number | 18228-17-6 | |
| Molecular Formula |
C17H13ClNO5P |
|
| Molecular Weight (MW) | 377.72 | |
| SMILES | C1=CC=C2C=C(C(=CC2=C1)C(=O)NC3=CC=C(C=C3)Cl)OP(=O)(O)O | |
| InChIKey | RQAQWBFHPMSXKR-UHFFFAOYSA-N |
KG-501 is a CREB inhibitor that disrupts CREB-dependent transcription (Ki =, CREB:CBP interaction (Ki =, and phospho (Ser-133) CREB binding to the KIX domain (Ki ≈. By blocking the interaction between phosphorylated CREB and the KIX domain of CBP/p300, KG-501 attenuates cAMP-responsive gene transcription and downstream signal transduction pathways. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
20 mg/mL
(52.94 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.