CAS No. 2455480-28-9
Batch:
Purity:99.54
Chemical Structure
Check the
EP4-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[1-[[1-(1-benzofuran-2-ylmethyl)indole-7-carbonyl]amino]cyclopropyl]bicyclo[1.1.1]pentane-1-carboxylic acid | |
|---|---|---|
| CAS Number | 2455480-28-9 | |
| Molecular Formula |
C27H24N2O4 |
|
| Molecular Weight (MW) | 440.49 | |
| InChIKey | VXNXZITXYGATRA-UHFFFAOYSA-N |
EP4-IN-1 is a potent prostanoid EP4 receptor inhibitor. By antagonizing the G protein-coupled EP4 receptor, EP4-IN-1 disrupts prostaglandin E2 (PGE2)-mediated cAMP signaling and downstream immunosuppressive cascades within the tumor microenvironment. Consequently, inhibition of this receptor axis enhances anti-tumor immune responses and modulates nociceptive pathway activation, supporting research in tumor immunity and anti-inflammatory analgesia. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
88 mg/mL
(199.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 22 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.