CAS No. 74103-07-4

Batch: Purity:99.92
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Ketorolac tromethamine salt Chemical Structure
Chemical Structure
Check the Ketorolac tromethamine salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-amino-2-(hydroxymethyl)propane-1,3-diol;5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid
CAS Number 74103-07-4
Molecular Formula

C19H24N2O6
Molecular Weight (MW) 376.4
SMILES C1CN2C(=CC=C2C(=O)C3=CC=CC=C3)C1C(=O)O.C(C(CO)(CO)N)O
InChIKey BWHLPLXXIDYSNW-UHFFFAOYSA-N

Ordering Information

Biological Activity

Ketorolac tromethamine salt is a non-selective cyclooxygenase (COX) inhibitor that targets both COX-1 and COX-2 isoforms. By inhibiting COX activity, it prevents the conversion of arachidonic acid into prostaglandins, thereby reducing pro-inflammatory mediator synthesis. This blockade suppresses downstream inflammatory signaling pathways and attenuates pain, fever, and tissue inflammation, conferring potent analgesic, anti-inflammatory, and antipyretic biological phenotypes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 75 mg/mL (199.25 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 75 mg/mL
Ethanol 8 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.