CAS No. 2102501-84-6

Batch: Purity:99.59
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Ketohexokinase inhibitor 1 Chemical Structure
Chemical Structure
Check the Ketohexokinase inhibitor 1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[(1R,5S)-3-[2-[(2S)-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]acetic acid
CAS Number 2102501-84-6
Molecular Formula

C16H19F3N4O2
Molecular Weight (MW) 356.34
InChIKey MDUYWDNWFXSMJJ-OFLUOSHYSA-N

Ordering Information

Biological Activity

Ketohexokinase inhibitor 1 (PF-06835919) is a potent, isoform-selective ketohexokinase (KHK) inhibitor targeting KHK-C (IC50 = and KHK-A (IC50 =. By blocking KHK-mediated phosphorylation of dietary fructose to fructose-1-phosphate, it disrupts the hepatic fructolysis pathway. This targeted inhibition reduces fructose-driven lipogenesis, suppresses hepatic lipid accumulation, and mitigates metabolic dysfunction associated with fatty liver diseases. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (199.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 71 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.