CAS No. 1513879-19-0
Batch:
Purity:99.67
Chemical Structure
Check the
KDU691
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(4-chlorophenyl)-N-methyl-3-[4-(methylcarbamoyl)phenyl]imidazo[1,2-a]pyrazine-6-carboxamide | |
|---|---|---|
| CAS Number | 1513879-19-0 | |
| Molecular Formula |
C22H18ClN5O2 |
|
| Molecular Weight (MW) | 419.86 | |
| SMILES | CNC(=O)C1=CC=C(C=C1)C2=CN=C3N2C=C(N=C3)C(=O)N(C)C4=CC=C(C=C4)Cl | |
| InChIKey | TYMFFISSODJRDV-UHFFFAOYSA-N |
KDU691 is a potent imidazopyrazine-class inhibitor targeting Plasmodium phosphatidylinositol 4-kinase (PI4K). By selectively inhibiting PI4K activity, KDU691 disrupts critical intracellular lipid signaling and membrane trafficking pathways across multiple parasite stages. This inhibition effectively suppresses both liver schizonts and hypnozoite forms of Plasmodium, leading to the blockage of liver-stage parasite development and prevention of disease transmission. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.