CAS No. 1628210-26-3
Batch:
Purity:99.89
Chemical Structure
Check the
KDM5-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-(1-tert-butylpyrazol-4-yl)-7-oxo-6-propan-2-yl-1H-pyrazolo[1,5-a]pyrimidine-3-carbonitrile | |
|---|---|---|
| CAS Number | 1628210-26-3 | |
| Molecular Formula |
C17H20N6O |
|
| Molecular Weight (MW) | 324.38 | |
| InChIKey | YQCOPPONWZNBQO-UHFFFAOYSA-N |
KDM5-IN-1 is a potent and selective small-molecule inhibitor of the KDM5 family of histone demethylases. By blocking KDM5 demethylase activity, this compound increases global levels of histone H3 lysine 4 trimethylation (H3K4me3), altering downstream gene transcription programs. Consequently, targeted inhibition of KDM5 attenuates cancer cell proliferation, disrupts slow-cycling tumor cell subpopulations, and suppresses tumorigenic phenotype maintenance. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
65 mg/mL
(200.38 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.