CAS No. 73981-34-7
Chemical Structure
Check the
kamebakaurin
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (1R,2R,4R,8S,9R,10S,13S,16R)-2,8,16-trihydroxy-9-(hydroxymethyl)-5,5-dimethyl-14-methylidenetetracyclo[11.2.1.01,10.04,9]hexadecan-15-one | |
|---|---|---|
| CAS Number | 73981-34-7 | |
| Molecular Formula |
C20H30O5 |
|
| Molecular Weight (MW) | 350.45 | |
| InChIKey | WHSUEVLJUHPROF-BIGDWJEQSA-N |
Kamebakaurin is a natural ent-kaurane diterpene that acts as a potent inhibitor of nuclear factor-kappa B (NF-kB) activation by directly targeting the DNA-binding activity of the p50 subunit. Blockade of NF-kB signaling suppresses the transcription of antiapoptotic target genes, enhances caspase-8 activation, and sensitizes cells to stimulus-induced apoptosis. Furthermore, kamebakaurin inhibits the JNK and p38 MAPK pathways, suppressing pro-inflammatory mediator production and neuroinflammatory responses.[1][2]
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Note: Technical data last updated: Sep 1, 2026.