CAS No. 1309444-75-4
Batch:
Purity:99.81
Chemical Structure
Check the
K145
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (5Z)-3-(2-aminoethyl)-5-[3-(4-butoxyphenyl)propylidene]-1,3-thiazolidine-2,4-dione | |
|---|---|---|
| CAS Number | 1309444-75-4 | |
| Molecular Formula |
C18H24N2O3S |
|
| Molecular Weight (MW) | 348.46 | |
| SMILES | CCCCOC1=CC=C(CC\C=C2/SC(=O)N(CCN)C2=O)C=C1 | |
| InChIKey | MPZXLTZVPUSTFY-SOFYXZRVSA-N |
K145 is a selective, substrate-competitive sphingosine kinase-2 (SphK2) inhibitor with an ICofand a Ki of. By suppressing intracellular sphingosine-1-phosphate (S1P) levels and inhibiting ERK and AKT signaling pathways, K145 induces apoptosis and suppresses cell proliferation. Furthermore, it demonstrates oral bioavailability and inhibits tumor growth in xenograft models in vivo. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(200.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 17 mg/mL |
| Water | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.