CAS No. 84783-01-7
Batch:
Purity:98.56
Chemical Structure
Check the
K-Ras-IN-1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2-hydroxyphenyl)-pyrrolidin-1-ylmethanethione | |
|---|---|---|
| CAS Number | 84783-01-7 | |
| Molecular Formula |
C11H13NOS |
|
| Molecular Weight (MW) | 207.29 | |
| SMILES | C1CCN(C1)C(=S)C2=CC=CC=C2O | |
| InChIKey | QIKLOVZAPGSYNO-UHFFFAOYSA-N |
K-Ras-IN-1 is a small-molecule K-Ras inhibitor that targets a distinct hydrophobic pocket occupied by Tyr-71 in the apo-Ras crystal structure. By binding within this site, it disrupts SOS-mediated guanine nucleotide exchange and prevents Ras activation. Consequently, this block suppresses downstream oncogenic signaling pathways, including MAPK and PI3K/AKT, thereby impairing cell proliferation in Ras-driven cancer cells. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
41 mg/mL
(197.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 41 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.