CAS No. 1469337-95-8
Batch:
Purity:99.06
-inhibitor-12-chemical-structure-s7331.gif)
Chemical Structure
Check the
K-Ras(G12C) inhibitor 12
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[4-[2-(4-chloro-2-hydroxy-5-iodoanilino)acetyl]piperazin-1-yl]prop-2-en-1-one | |
|---|---|---|
| CAS Number | 1469337-95-8 | |
| Molecular Formula |
C15H17ClIN3O3 |
|
| Molecular Weight (MW) | 449.67 | |
| SMILES | C=CC(=O)N1CCN(CC1)C(=O)CNC2=CC(=C(C=C2O)Cl)I | |
| InChIKey | JFIFBWVNHLXJFY-UHFFFAOYSA-N |
K-Ras(G12C) inhibitor 12 is a selective allosteric inhibitor targeting mutant K-Ras(G12C). By covalently binding to the cysteine 12 residue within the switch II pocket, the compound locks K-Ras in an inactive GDP-bound state and impairs effector interactions. This allosteric inhibition blocks downstream MAPK/ERK signaling, suppressing cell proliferation and inducing apoptosis in K-Ras(G12C)-mutated cancer cells. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
89 mg/mL
(197.92 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| 0.5MNAOH | 3 mg/mL |
| DMSO |
0.01 mg/mL
(0.02 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- K-Ras(G12C) inhibitor 12 Clinical Trials
- K-Ras(G12C) inhibitor 12 Solubility in DMSO
- K-Ras(G12C) inhibitor 12 Stock Solution
- K-Ras(G12C) inhibitor 12 Storage
- K-Ras(G12C) inhibitor 12 Stability
- K-Ras(G12C) inhibitor 12 Molecular Weight
- K-Ras(G12C) inhibitor 12 SMILES
- K-Ras(G12C) inhibitor 12 Chemical Structure (2D and 3D)
- K-Ras(G12C) inhibitor 12 SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.