CAS No. 339103-05-8
Batch:
Purity:99.98
Chemical Structure
Check the
JY-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 5-(2,4-dichlorophenyl)-3-pyridin-2-yl-1,2,4-oxadiazole | |
|---|---|---|
| CAS Number | 339103-05-8 | |
| Molecular Formula |
C13H7Cl2N3O |
|
| Molecular Weight (MW) | 292.12 | |
| InChIKey | WBMHQMQALJDGHI-UHFFFAOYSA-N |
Biological Activity
JY-2 is a selective and orally active inhibitor of the transcription factor forkhead box O1 (FoxO1) that also exerts moderate inhibitory effects on FoxO3a and FoxO4. By suppressing FoxO1-driven transcriptional activity, JY-2 attenuates downstream gluconeogenic gene expression and metabolic signaling pathways. Consequently, targeted inhibition of FoxO1 produces therapeutic anti-diabetic efficacy across cellular and preclinical metabolic disease phenotypes. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.