CAS No. 3110272-60-8
Chemical Structure
Check the
JWZ-8-103
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 3110272-60-8 | |
|---|---|---|
| Molecular Formula |
C21H22ClFN4O2 |
|
| Molecular Weight (MW) | 416.88 |
Biological Activity
JWZ-8-103 is an orally bioavailable molecular glue targeting TRIM21, an E3 ubiquitin ligase that recruits intracellular targets for proteasomal degradation. It promotes the interaction between the TRIM21 PRYSPRY domain and NUP98 to induce selective degradation of the nuclear pore complex. This disruption impairs nuclear pore stability, leading to potent antitumor activity in pancreatic cancer xenografts and patient-derived organoids. [1]
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Note: Technical data last updated: Sep 1, 2026.