CAS No. 1416133-89-5
Batch:
Purity:99.88
Chemical Structure
Check the
JW642
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1,1,1,3,3,3-hexafluoropropan-2-yl 4-[(3-phenoxyphenyl)methyl]piperazine-1-carboxylate | |
|---|---|---|
| CAS Number | 1416133-89-5 | |
| Molecular Formula |
C21H20F6N2O3 |
|
| Molecular Weight (MW) | 462.39 | |
| SMILES | FC(F)(F)C(OC(=O)N1CCN(CC1)CC2=CC=CC(=C2)OC3=CC=CC=C3)C(F)(F)F | |
| InChIKey | AVSCNEOUWSVZEY-UHFFFAOYSA-N |
Biological Activity
JW642 is a potent small-molecule inhibitor of monoacylglycerol lipase (MAGL). By inactivating MAGL, JW642 prevents the degradation of the primary endocannabinoid 2-arachidonoylglycerol (2-AG) in brain tissues. This inhibition leads to accumulation of 2-AG, enhancing cannabinoid receptor-mediated signaling pathways. Consequently, MAGL blockade modulates central nervous system endocannabinoid tone, attenuating pro-inflammatory arachidonic acid pools, dampening neuroinflammation, and inducing downstream antinociceptive responses in neural networks. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
92 mg/mL
(198.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 46 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.