CAS No. 481-39-0
Batch:
Purity:98
Chemical Structure
Check the
Juglone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 5-hydroxynaphthalene-1,4-dione | |
|---|---|---|
| CAS Number | 481-39-0 | |
| Molecular Formula |
C10H6O3 |
|
| Molecular Weight (MW) | 174.15 | |
| InChIKey | KQPYUDDGWXQXHS-UHFFFAOYSA-N |
Juglone is a natural naphthoquinone compound that acts as an inhibitor of peptidyl-prolyl cis-trans isomerases, including Pin1. By inactivating parvulin-like peptidyl-prolyl isomerases, Juglone disrupts cellular signaling and cell cycle progression. Additionally, Juglone generates reactive oxygen species, inducing oxidative stress and promoting apoptotic cell death. These biological effects contribute to its reported antifungal and herbicidal activities. [1]
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
34 mg/mL
(195.23 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.