CAS No. 2411440-41-8
Batch:
Purity:99.54
Chemical Structure
Check the
JR14a
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-[[5-[bis(4-chlorophenyl)methyl]-3-methylthiophene-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid | |
|---|---|---|
| CAS Number | 2411440-41-8 | |
| Molecular Formula |
C25H26Cl2N4O3S |
|
| Molecular Weight (MW) | 533.47 | |
| SMILES | CC1=C(SC(=C1)C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)C(=O)NC(CCCNC(N)=N)C(O)=O | |
| InChIKey | OHRIKWUZKGNQKQ-IBGZPJMESA-N |
JR14a is a potent and selective human complement C3a receptor (C3aR) antagonist that inhibits C3a-induced intracellular calcium release with an IC50 of 10 nM and β-hexosaminidase secretion with an IC50 of 8 nM, exhibiting selectivity for C3aR over C5aR. Blockade of C3aR signaling suppresses complement-mediated inflammatory pathways, attenuating macrophage and mast cell activation as well as inflammatory edema in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(187.45 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.