CAS No. 202592-23-2
Batch:
Purity:99.98
Chemical Structure
Check the
(+)-JQ1 carboxylic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]acetic acid | |
|---|---|---|
| CAS Number | 202592-23-2 | |
| Molecular Formula |
C19H17ClN4O2S |
|
| Molecular Weight (MW) | 400.88 | |
| SMILES | CC1=C(C)C2=C(S1)[N]3C(=NN=C3C(CC(O)=O)N=C2C4=CC=C(Cl)C=C4)C | |
| InChIKey | LJOSBOOJFIRCSO-AWEZNQCLSA-N |
(+)-JQ1 carboxylic acid is a functionalized derivative of the BET bromodomain inhibitor (+)-JQ1 containing a terminal carboxylic acid moiety. It serves as a key chemical precursor and recruiting element for the synthesis of proteolysis targeting chimeras (PROTACs) targeting BET bromodomains. When conjugated to linkers and E3 ligase ligands, JQ1 derivatives enable targeted ubiquitin-proteasome degradation of BET proteins such as BRD4, resulting in suppressed oncogenic transcription and inhibition of cancer cell proliferation. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
80 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
80 mg/mL
(199.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- (+)-JQ1 carboxylic acid Solubility in DMSO
- (+)-JQ1 carboxylic acid Stock Solution
- (+)-JQ1 carboxylic acid Storage
- (+)-JQ1 carboxylic acid Stability
- (+)-JQ1 carboxylic acid Molecular Weight
- (+)-JQ1 carboxylic acid SMILES
- (+)-JQ1 carboxylic acid Chemical Structure (2D and 3D)
- (+)-JQ1 carboxylic acid SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.