CAS No. 894804-07-0
Batch:
Purity:99.77
Chemical Structure
Check the
JNK Inhibitor VIII
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2-(2,5-dimethoxyphenyl)acetamide | |
|---|---|---|
| CAS Number | 894804-07-0 | |
| Molecular Formula |
C18H20N4O4 |
|
| Molecular Weight (MW) | 356.38 | |
| SMILES | CCOC1=C(C(=CC(=N1)NC(=O)CC2=C(C=CC(=C2)OC)OC)N)C#N | |
| InChIKey | KQMPRSZTUSSXND-UHFFFAOYSA-N |
JNK Inhibitor VIII (TCS JNK 6o) is a potent inhibitor of c-Jun N-terminal kinase isoforms, specifically JNK1, JNK2, and JNK3. By suppressing JNK kinase activity, it blocks downstream c-Jun phosphorylation and AP-1-mediated transcriptional activation. Consequently, inhibition of this stress-activated MAPK pathway suppresses apoptotic signaling cascades and inflammatory cytokine expression in cellular response models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
71 mg/mL
(199.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.