CAS No. 312917-14-9

Batch: Purity:99.91
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JNK Inhibitor IX Chemical Structure
Chemical Structure
Check the JNK Inhibitor IX product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
CAS Number 312917-14-9
Molecular Formula

C20 H16 N2 O S
Molecular Weight (MW) 332.42
SMILES C1CCC2=C(C1)C(=C(S2)NC(=O)C3=CC=CC4=CC=CC=C43)C#N
InChIKey WQGDQGAFSDMBLA-UHFFFAOYSA-N

Biological Activity

JNK Inhibitor IX is a selective c-Jun N-terminal kinase inhibitor that targets JNK2 and JNK3 isoforms. By suppressing JNK activity within the MAPK pathway, this compound blocks the downstream phosphorylation of target transcription factors, including c-Jun. This inhibition disrupts stress-activated signaling cascades, thereby modulating gene expression, cellular stress responses, inflammatory mediator production, and apoptotic cell death. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 20 mg/mL (60.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Manning AM, et al. Nat Rev Drug Discov. 2003;2(7):554-65.

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Note: Technical data last updated: Sep 1, 2026.