CAS No. 1408064-71-0
Batch:
Purity:98.73
Chemical Structure
Check the
JNK-IN-7
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 3-[[(E)-4-(dimethylamino)but-2-enoyl]amino]-N-[4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | |
|---|---|---|
| CAS Number | 1408064-71-0 | |
| Molecular Formula |
C28H27N7O2 |
|
| Molecular Weight (MW) | 493.56 | |
| SMILES | CN(C)CC=CC(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(NC3=NC=CC(=N3)C4=CN=CC=C4)C=C2 | |
| InChIKey | RADRIIWGHYFWPP-WEVVVXLNSA-N |
JNK-IN-is a potent covalent inhibitor of c-Jun N-terminal kinase (JNK) isoforms, targeting JNK1, JNK2 (IC2 nM), and JNK3 (IC0.. By covalently modifying a conserved cysteine residue within the kinase domain, JNK-IN-blocks the phosphorylation of c-Jun, a direct downstream substrate in the MAPK pathway. This inhibition interrupts downstream transcription factor activation and dampens stress-mediated cellular signaling cascades. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
50 mg/mL
(101.3 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.