CAS No. 1428327-31-4
Batch:
Purity:99.80
Chemical Structure
Check the
JNJ-47965567
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl]-2-phenylsulfanylpyridine-3-carboxamide | |
|---|---|---|
| CAS Number | 1428327-31-4 | |
| Molecular Formula |
C28H32N4O2S |
|
| Molecular Weight (MW) | 488.65 | |
| SMILES | O=C(NCC1(CCOCC1)N2CCN(CC2)C3=CC=CC=C3)C4=C(SC5=CC=CC=C5)N=CC=C4 | |
| InChIKey | XREFXUCWSYMIOG-UHFFFAOYSA-N |
JNJ-47965567 is a centrally permeable, high-affinity, and selective antagonist of the purinergic P2X7 receptor. Inhibition of P2X7 receptor signaling disrupts ATP-driven ion channel activation and downstream neuroinflammatory pathways, suppressing agonist-induced pore formation and IL-1β release. In central nervous system models, JNJ-47965567 reduces microglial activation, demonstrates robust central target engagement, and attenuates behavioral phenotypes such as amphetamine-induced hyperlocomotion. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(200.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.