CAS No. 1252765-13-1
Batch:
Purity:99.50
Chemical Structure
Check the
JNJ-42226314
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [1-(4-fluorophenyl)indol-5-yl]-[3-[4-(1,3-thiazole-2-carbonyl)piperazin-1-yl]azetidin-1-yl]methanone | |
|---|---|---|
| CAS Number | 1252765-13-1 | |
| Molecular Formula |
C26H24FN5O2S |
|
| Molecular Weight (MW) | 489.57 | |
| InChIKey | IVOACCSOISMVBL-UHFFFAOYSA-N |
JNJ-42226314 is a potent, selective, and reversible noncovalent inhibitor of monoacylglycerol lipase (MAGL). By suppressing MAGL-mediated degradation of endocannabinoids, this compound effectively elevates endogenous 2-arachidonoylglycerol (2-AG) levels in tissue and indirectly drives cannabinoid CB1 receptor occupancy. Downstream, JNJ-42226314 demonstrates robust antinociceptive efficacy in rodent preclinical models of both inflammatory and neuropathic pain. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
98 mg/mL
(200.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.