CAS No. 878489-28-2

Batch: Purity:99.5
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JNJ 303 Chemical Structure
Chemical Structure
Check the JNJ 303 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(4-chlorophenoxy)-N-[(1R,3S)-5-(methanesulfonamido)-2-adamantyl]-2-methylpropanamide
CAS Number 878489-28-2
Molecular Formula

C21H29ClN2O4S
Molecular Weight (MW) 440.98
SMILES CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)NS(=O)(=O)C)OC4=CC=C(C=C4)Cl
InChIKey OSGIRCJRKSAODN-DJASPMHUSA-N

Ordering Information

Biological Activity

JNJ 303 is a potent inhibitor of the voltage-dependent IKs channel encoded by the KCNQ1/KCNE1 potassium channel complex, displaying an IC50 of 64 nM. Blockade of this repolarizing current impairs cardiac action potential duration and delays ventricular repolarization, resulting in marked QT interval prolongation. Consequently, JNJ 303 disrupts normal cardiac electrophysiology and predisposes ventricular tissue to unprovoked torsades de pointes.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 88 mg/mL (199.55 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.