CAS No. 1380392-05-1

Batch: Purity:99.96
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JMS-17-2 Chemical Structure
Chemical Structure
Check the JMS-17-2 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-[3-[4-(4-chlorophenyl)piperidin-1-yl]propyl]pyrrolo[1,2-a]quinoxalin-4-one
CAS Number 1380392-05-1
Molecular Formula

C25H26ClN3O
Molecular Weight (MW) 419.95
SMILES C1CN(CCC1C2=CC=C(C=C2)Cl)CCCN3C4=CC=CC=C4N5C=CC=C5C3=O
InChIKey WOSMCMULWWHMIV-UHFFFAOYSA-N

Ordering Information

Biological Activity

JMS-17-2 is a potent small-molecule antagonist of CX3C chemokine receptor 1 (CX3CR1) with an IC50 of 0.32 nM. By selectively targeting CX3CR1, JMS-17-2 blocks downstream chemokine signaling pathways, inhibiting receptor-mediated cellular adhesion, chemotactic migration, and tumor cell survival. Consequently, blockade of CX3CR1 activity impairs cell motility and suppresses metastatic dissemination in breast cancer disease models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 40 mg/mL (95.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.