CAS No. 2079938-92-2
Batch:
Purity:99.39
Chemical Structure
Check the
JHU395
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | propan-2-yl (2S)-6-diazo-2-[[2,2-dimethylpropanoyloxy(phenyl)methoxy]carbonylamino]-5-oxohexanoate | |
|---|---|---|
| CAS Number | 2079938-92-2 | |
| Molecular Formula |
C22H29N3O7 |
|
| Molecular Weight (MW) | 447.48 | |
| SMILES | CC(C)OC(=O)C(CCC(=O)C=[N+]=[N-])NC(=O)OC(OC(=O)C(C)(C)C)C1=CC=CC=C1 | |
| InChIKey | QQIBFRQTTLIECS-KKFHFHRHSA-N |
Biological Activity
JHU395 is an orally bioavailable glutamine antagonist prodrug designed to selectively deliver active glutamine antagonists to target tissues while remaining inert in plasma. By inhibiting glutamine-utilizing metabolic pathways, JHU395 disrupts cellular nutrient utilization and energy production in glutamine-dependent tumor cells. This metabolic blockade impairs cell proliferation and suppresses tumor growth in malignant peripheral nerve sheath tumor models without inducing significant systemic toxicity. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(223.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer longer shelf life compared to stock solutions.
Looking for a specific aliquot size? Contact your local sales representative or orders@selleckchem.com.
Reference
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Note: Technical data last updated: Sep 1, 2026.