CAS No. 1361227-90-8
Batch:
Purity:99.94
Chemical Structure
Check the
JH-RE-06
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 8-chloro-2-(2,4-dichloroanilino)-3-(3-methylbutanoyl)-5-nitro-1H-quinolin-4-one | |
|---|---|---|
| CAS Number | 1361227-90-8 | |
| Molecular Formula |
C20H16Cl3N3O4 |
|
| Molecular Weight (MW) | 468.72 | |
| SMILES | CC(C)CC(=O)C1=C(NC2=C(C=CC(=C2C1=O)[N+](=O)[O-])Cl)NC3=C(C=C(C=C3)Cl)Cl | |
| InChIKey | LRTXIQCBQIKIOH-UHFFFAOYSA-N |
JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and a Kd of 0.42 μM for REV1 binding, which disrupts REV1-POL ζ-mediated mutagenic translesion synthesis. By blocking this protein-protein interaction, JH-RE-06 inhibits error-prone DNA lesion bypass, suppresses chemotherapy-induced mutagenesis, and enhances the cytotoxic effects of DNA-damaging agents such as cisplatin in cancer cell lines and animal models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
40 mg/mL
(85.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
12 mg/mL
(25.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.