CAS No. 2887480-87-5
Chemical Structure
Check the
JG-2016
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 7-chloro-8-ethyl-10-[2-(2-methylpropoxy)ethyl]benzo[g]pteridine-2,4-dione | |
|---|---|---|
| CAS Number | 2887480-87-5 | |
| Molecular Formula |
C18H21ClN4O3 |
|
| Molecular Weight (MW) | 376.84 | |
| InChIKey | IOHJEWFKBRNJIO-UHFFFAOYSA-N |
Biological Activity
JG-2016 is a potent and selective inhibitor of histone acetyltransferase 1 (HAT1) that targets the HAT1:Rbap46 complex. By blocking HAT1-mediated histone acetylation, JG-2016 impairs chromatin assembly and downstream epigenetic regulation. Consequently, this compound exhibits strong anti-proliferative activity across multiple carcinoma cell lines, including A549, HCC1806, and HCC1937, and significantly suppresses tumor growth in A549 xenograft models.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Jump to
Note: Technical data last updated: Sep 1, 2026.