CAS No. 2653994-08-0

Batch: Purity:99.33
Check CoA
Opnurasib (JDQ-443) Chemical Structure
Chemical Structure
Check the Opnurasib (JDQ-443) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[6-[4-(5-chloro-6-methyl-1H-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]prop-2-en-1-one
CAS Number 2653994-08-0
Molecular Formula

C29H28CIN7O
Molecular Weight (MW) 526.03
InChIKey AZUYLZMQTIKGSC-UHFFFAOYSA-N

Biological Activity

Opnurasib (JDQ-443) is an orally bioavailable, selective covalent inhibitor of GDP-bound KRAS G12C that inhibits c-Raf recruitment with an ICof. By trapping KRAS G12C in an inactive GDP-bound state, it disrupts interaction with effector proteins and suppresses downstream MAPK pathway signaling, leading to inhibition of cellular proliferation in KRAS G12C-mutated tumor models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (190.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Weiss A, et al. Cancer Discov. 2022;12(6):1500-1517.

Jump to

Note: Technical data last updated: Sep 1, 2026.