CAS No. 6681-15-8
Batch:
Purity:99.95
Chemical Structure
Check the
Jatrorrhizine chloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol chloride | |
|---|---|---|
| CAS Number | 6681-15-8 | |
| Molecular Formula |
C20H20ClNO4 |
|
| Molecular Weight (MW) | 373.83 | |
| SMILES | COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC.[Cl-] | |
| InChIKey | JKMUUZMCSNHBAX-UHFFFAOYSA-N |
Jatrorrhizine chloride is a protoberberine alkaloid and potent acetylcholinesterase (AChE) inhibitor with over 115-fold selectivity for AChE over butyrylcholinesterase (BuChE). By inhibiting AChE, it blocks acetylcholine hydrolysis, enhancing cholinergic neurotransmission and neuroprotective signaling pathways. This activity attenuates amyloid-beta accumulation, improves cognitive function, and exhibits antioxidant and anti-inflammatory properties in neuronal cell models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 6 mg/mL |
| DMSO |
2 mg/mL
(5.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) |
| Water | 2 mg/mL |
| DMSO |
4 mg/mL
(10.7 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.