CAS No. 2245082-05-5

Batch: Purity:99.87
Check CoA
JAB-3312 Chemical Structure
Chemical Structure
Check the JAB-3312 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (5S)-1'-[5-[(2-amino-3-chloro-4-pyridinyl)sulfanyl]pyrazin-2-yl]spiro[5,7-dihydrocyclopenta[b]pyridine-6,4'-piperidine]-5-amine
CAS Number 2245082-05-5
Molecular Formula

C21H22ClN7S
Molecular Weight (MW) 439.97
InChIKey GKGIGIUNYOFYHZ-LJQANCHMSA-N

Biological Activity

JAB-3312 is a potent allosteric inhibitor of Src homology 2 domain-containing phosphatase 2 (SHP2). By binding to the allosteric site, it stabilizes SHP2 in an inactive conformation, thereby disrupting receptor tyrosine kinase-mediated signaling. Inhibition of SHP2 blocks activation of the downstream RAS/MAPK pathway, leading to suppression of cellular proliferation and inhibition of tumor growth in RTK-driven cancer models. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 29 mg/mL (65.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Chen YN, et al. Nature. 2016;535(7610):148-52.

[2] Yuan J, et al. J Hematol Oncol. 2020;13(1):113.

Jump to

Note: Technical data last updated: Sep 1, 2026.