CAS No. 2169223-48-5
Batch:
Purity:99.67
Chemical Structure
Check the
JAB-3068
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 1-[4-[3-amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl]pyrazin-2-yl]sulfanyl-3,3-difluoro-2H-indol-1-yl]ethanone | |
|---|---|---|
| CAS Number | 2169223-48-5 | |
| Molecular Formula |
C22H26F2N6O2S |
|
| Molecular Weight (MW) | 476.54 | |
| InChIKey | HGYTYZKWKUXRKA-MRXNPFEDSA-N |
Biological Activity
JAB-is a potent allosteric inhibitor of Src homology 2 domain-containing phosphatase 2 (SHP2). By selectively blocking SHP2, it disrupts receptor tyrosine kinase signaling and suppresses downstream RAS/MAPK pathway activation. Furthermore, JAB-enhances the anti-tumor cytotoxic activity of CD8+ T cells and can be combined with PD-1/PD-L1 antibodies to target non-responsive tumors. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(199.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.