CAS No. 1127442-82-3
Batch:
Purity:99.94
Chemical Structure
Check the
IWR-1-endo
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[(1R,2S,6R,7S)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide | |
|---|---|---|
| CAS Number | 1127442-82-3 | |
| Molecular Formula |
C25H19N3O3 |
|
| Molecular Weight (MW) | 409.44 | |
| SMILES | C1C2C=CC1C3C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6 | |
| InChIKey | ZGSXEXBYLJIOGF-ALFLXDJESA-N |
IWR-1-endo is a Wnt pathway inhibitor that suppresses Wnt/β-catenin signaling with an IC50 ofin Wnt3A-expressing L-cells. By stabilizing Axin-scaffolded destruction complexes, IWR-1-endo increases Axin2 protein levels and enhances β-catenin phosphorylation. This increased phosphorylation targets β-catenin for degradation, thereby downregulating downstream Wnt-dependent gene expression and modulating cell proliferation in Wnt-driven signaling models.
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(200.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
15 mg/mL
(36.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
41 mg/mL
(100.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
30 mg/mL
(73.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
82 mg/mL
(200.27 mM)
; Ultrasonicated
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- IWR-1-endo Mechanism of Action: Tankyrase Inhibition in Cancer Stem Cells Research
- IWR-1-endo Working Concentration | Cell Culture | Treatment
- IWR-1-endo Solubility in DMSO
- IWR-1-endo Stock Solution
- IWR-1-endo Storage
- IWR-1-endo Stability
- IWR-1-endo Combination Database
- IWR-1-endo Molecular Weight
- IWR-1-endo SMILES
- IWR-1-endo Chemical Structure (2D and 3D)
- IWR-1-endo IC50 for Cell-based and Cell-free Assays
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- IWR-1-endo SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.