IWP-2 is a potent Porcupine inhibitor. By blocking Wnt protein secretion and subsequent β-catenin-mediated transcription, it suppresses Wnt/β-catenin signaling, thereby inhibiting cancer cell proliferation, migration, and EMT, while also promoting lineage-specific differentiation in stem cell models.
IWP-2: Mechanism of Action
IWP-2 MOA：Targeting Porcupine/Wnt Signaling Pathway for Oncology and Cancer Research