IWP-2 is a potent Porcupine inhibitor. By blocking Wnt protein secretion and subsequent β-catenin-mediated transcription, it suppresses Wnt/β-catenin signaling, thereby inhibiting cancer cell proliferation, migration, and EMT, while also promoting lineage-specific differentiation in stem cell models.
IWP-2 IC50 for Cell-based and Cell-free Assays
Comprehensive IC50 Values for IWP-2 Across Cell-free Enzyme Inhibitory Profiles and Cell-based Functional Assays.