CAS No. 873054-44-5

Batch: Purity:99.96
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Ivacaftor (VX-770) Chemical Structure
Chemical Structure
Check the Ivacaftor (VX-770) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide
CAS Number 873054-44-5
Molecular Formula

C24H28N2O3
Molecular Weight (MW) 392.49
SMILES CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C
InChIKey PURKAOJPTOLRMP-UHFFFAOYSA-N

Biological Activity

Ivacaftor (VX-770) is a selective CFTR potentiator targeting G551D-CFTR (EC50 of 100 nM) and F508del-CFTR (EC50 of 25 nM). It increases CFTR channel open probability to enhance chloride ion secretion across airway epithelial cells. This process attenuates excessive sodium and fluid absorption to prevent surface dehydration and restore cilia beating frequency in cystic fibrosis models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (198.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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Reference

[1] Van DuyneGD. Proc. Natl. Acad. Sci. U.S.A. 2009;106(1):4-5.

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Note: Technical data last updated: Sep 1, 2026.