lutein

Catalog No.S5103 Synonyms: Xanthophyll, Xantofyl

For research use only.

Lutein (Xanthophyll, Xantofyl) is a vitamin-like carotenoid produced by plants, which contributes to the colour of some fruit and vegetables. It is a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.

lutein Chemical Structure

CAS No. 127-40-2

Selleck's lutein has been cited by 1 Publication

Purity & Quality Control

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Biological Activity

Description Lutein (Xanthophyll, Xantofyl) is a vitamin-like carotenoid produced by plants, which contributes to the colour of some fruit and vegetables. It is a lipid-soluble antioxidant that can circulate in the plasma and confer cardioprotective, anti-inflammatory, and anti-angiogenic effects.
In vitro

The ED50 value of lutein as a free radical scavenger is 0.7 μM. Apart from the ROS scavenger property of lutein, lutein suppresses the activation of the nuclear factor (NF)-κB and the degradation of the inhibitor-κB (IκB)[1]. Lutein has been shown to have effect, not only on retinal pigment epithelium (RPE), but also on other cellular components including ganglion cells, inner plexiform and nuclear layers, and even photoreceptors[2]. Lutein significantly reduces the cisplatin-induced cytotoxicity in the HEI-OC1 cells when they are pre-treated with lutein concentrations of 60 and 80 μM[3].

In vivo The antioxidant properties of lutein contribute to the protection against LPS-induced uveitis, partially through the intervention of inflammation process[1]. Lutein is anti-apoptotic in rodent models of ischemia/reperfusion injury and also a potent neuroprotective agent that can salvage photoreceptors in rats with retinal detachment, with a therapeutic window of at least 36 h. Lutein has anti-oxidative properties in the eye. It absorbs blue light and contains double bonds that quench reactive oxygen species, therefore reducing oxidative stress[2].

Protocol (from reference)

Cell Research:

[3]

  • Cell lines: HEI-OC1 cells
  • Concentrations: 2.5-100 μM
  • Incubation Time: 24 h
  • Method:

    Lutein toxicity assay: HEI-OC1 cells are seeded in 96-well plates, with each well containing 3×104 cells. After 24 h incubation under permissive conditions (33 ℃, 10% CO2 in DMEM), the cells are treated with various lutein dilutions (2.5, 5, 10, 20, 30, 40, 60, 80 or 100 μM) and viability assessed after 24 h.

  • (Only for Reference)
Animal Research:

[1]

  • Animal Models: BALB/C mice
  • Dosages: 125 and 500 mg/kg/d
  • Administration: oral
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 20 mg/mL
(35.15 mM)
Ethanol 10 mg/mL
(17.57 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 568.87
Formula

C40H56O2

CAS No. 127-40-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2C(=CC(CC2(C)C)O)C)C)C

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04779398 Recruiting -- Age Related Macular Degeneration The University of Queensland September 25 2020 --
NCT03340103 Withdrawn Dietary Supplement: LUTEIN ofta 05 gocce|Drug: Placebo Antioxidant Role of the Lutein in Preterm Newborn Sooft Italia|Fondazione Poliambulanza Istituto Ospedaliero|University of Siena|University Hospital Padova|University Hospital Perugia October 11 2018 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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