CAS No. 670270-31-2
Batch:
Purity:99.98
Chemical Structure
Check the
IU1-47
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-[1-(4-chlorophenyl)-2,5-dimethylpyrrol-3-yl]-2-piperidin-1-ylethanone | |
|---|---|---|
| CAS Number | 670270-31-2 | |
| Molecular Formula |
C19H23ClN2O |
|
| Molecular Weight (MW) | 330.85 | |
| SMILES | CC1=CC(=C(C)[N]1C2=CC=C(Cl)C=C2)C(=O)CN3CCCCC3 | |
| InChIKey | VXQIPRWKLACSKZ-UHFFFAOYSA-N |
IU1-47 is a synthetic small-molecule inhibitor targeting ubiquitin-specific processing protease 14 (USP14). By selectively inhibiting proteasome-associated USP14 deubiquitinase activity, the compound prevents the trimming of ubiquitin chains on substrate proteins. This inhibition enhances proteasomal degradation efficiency and promotes the accelerated clearance of neurotoxic proteins, such as tau, through the ubiquitin-proteasome pathway to regulate intracellular protein homeostasis. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Ethanol | 33 mg/mL |
| DMSO |
8 mg/mL
(24.18 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.