CAS No. 2307472-03-1
Batch:
Purity:99.41
Chemical Structure
Check the
Iu1-248
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[3-[2-(4-hydroxypiperidin-1-yl)acetyl]-2,5-dimethylpyrrol-1-yl]benzonitrile | |
|---|---|---|
| CAS Number | 2307472-03-1 | |
| Molecular Formula |
C20H23N3O2 |
|
| Molecular Weight (MW) | 337.42 | |
| SMILES | CC1=CC(=C(C)[N]1C2=CC=C(C=C2)C#N)C(=O)CN3CCC(O)CC3 | |
| InChIKey | WFOUOZGIXDMUJU-UHFFFAOYSA-N |
Iu1-248 is a potent derivative of IU1 that functions as a selective ubiquitin specific peptidase 14 (USP14) inhibitor with an ICof. By binding to a unique steric site in USP14, it blocks ubiquitin C-terminus access to the active site and abrogates USP14 deubiquitinating activity. Consequently, inhibition of proteasomal deubiquitination modulates protein degradation pathways and regulates cellular proteostasis.
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
67 mg/mL
(198.56 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.