CAS No. 122892-31-3
Batch:
Purity:99.97
Chemical Structure
Check the
Itopride hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[[4-[2-(dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxybenzamide;hydrochloride | |
|---|---|---|
| CAS Number | 122892-31-3 | |
| Molecular Formula |
C20H26N2O4.HCl |
|
| Molecular Weight (MW) | 394.89 | |
| SMILES | CN(C)CCOC1=CC=C(C=C1)CNC(=O)C2=CC(=C(C=C2)OC)OC.Cl | |
| InChIKey | ZTOUXLLIPWWHSR-UHFFFAOYSA-N |
Biological Activity
Itopride hydrochloride is a gastroprokinetic agent that acts as an acetylcholinesterase (AChE) inhibitor and dopamine D2 receptor antagonist. By inhibiting AChE-mediated enzymatic degradation of acetylcholine, it enhances endogenous cholinergic neurotransmission and increases acetylcholine availability. This stimulation of cholinergic signal transduction promotes gastrointestinal smooth muscle contraction and accelerates gastric motility, effectively enhancing upper digestive tract motility. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
78 mg/mL
(197.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 78 mg/mL |
| Ethanol | 38 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.