CAS No. 1642303-38-5
Batch:
Purity:99.177
Chemical Structure
Check the
ITI-214
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (11R,15S)-5-anilino-4-[[4-(6-fluoro-2-pyridinyl)phenyl]methyl]-8-methyl-1,3,4,8,10-pentazatetracyclo[7.6.0.02,6.011,15]pentadeca-2,5,9-trien-7-one;phosphoric acid | |
|---|---|---|
| CAS Number | 1642303-38-5 | |
| Molecular Formula |
C29H26FN7O.H3O4P |
|
| Molecular Weight (MW) | 605.56 | |
| InChIKey | ZPIAAFIYOPWWJL-RFPXDPOKSA-N |
ITI-214 is a potent, CNS-penetrant, and orally bioavailable phosphodiesterase-1 (PDE1) inhibitor that targets human PDE1A, PDE1B, and PDE1C isoforms. By inhibiting PDE1 enzymatic activity, ITI-214 blocks the hydrolysis of cyclic nucleotides, thereby elevating intracellular cAMP and cGMP levels to modulate downstream signaling cascades. These pathway alterations enhance neuronal function and offer potential therapeutic benefits for cognitive impairment associated with neurodegenerative and neuropsychiatric disorders.[1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(165.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.