CAS No. 2247608-27-9
Batch:
Purity:99.01
Chemical Structure
Check the
ITF3756
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-hydroxy-4-[(5-thiophen-2-yltetrazol-1-yl)methyl]benzamide | |
|---|---|---|
| CAS Number | 2247608-27-9 | |
| Molecular Formula |
C13H11N5O2S |
|
| Molecular Weight (MW) | 301.33 | |
| InChIKey | UFUGFWWXDWPEQE-UHFFFAOYSA-N |
Biological Activity
ITF3756 is a selective histone deacetylase 6 (HDAC6) inhibitor bearing a pentaheterocyclic scaffold. By dampening TNF-α pathway activation, ITF3756 downregulates PD-L1 expression and upregulates costimulatory CD40 expression in activated monocytes, promoting a less immunosuppressive phenotype and enhancing T-cell proliferation. In vivo, ITF3756 reduces tumor growth in murine colon cancer models, supporting its utility in cancer immunotherapy research. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
60 mg/mL
(199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.