CAS No. 1099644-42-4

Batch: Purity:99.98
Check CoA
ITD-1 Chemical Structure
Chemical Structure
Check the ITD-1 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name ethyl 2,7,7-trimethyl-5-oxo-4-(4-phenylphenyl)-1,4,6,8-tetrahydroquinoline-3-carboxylate
CAS Number 1099644-42-4
Molecular Formula

C27H29NO3
Molecular Weight (MW) 415.52
SMILES CCOC(=O)C1=C(NC2=C(C1C3=CC=C(C=C3)C4=CC=CC=C4)C(=O)CC(C2)(C)C)C
InChIKey ULFUJLFTRWWLPO-UHFFFAOYSA-N

Ordering Information

Biological Activity

ITD-1 is a selective TGF-β signaling inhibitor that targets type II TGF-β receptor (TGFBR2) without directly inhibiting the kinase activity of TGFBR1 or TGFBR2. By promoting TGFBR2 degradation, ITD-1 potently blocks TGF-β-induced effector SMAD2/3 phosphorylation while showing minimal effect on Activin A signaling. This inhibition downregulates downstream TGF-β pathway target genes and promotes cardiomyocyte differentiation from human pluripotent stem cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 83 mg/mL (199.74 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.