CAS No. 97-65-4
Batch:
Purity:98.15
Chemical Structure
Check the
Itaconic acid
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-methylidenebutanedioic acid | |
|---|---|---|
| CAS Number | 97-65-4 | |
| Molecular Formula |
C5H6O4 |
|
| Molecular Weight (MW) | 130.10 | |
| SMILES | OC(=O)CC(=C)C(O)=O | |
| InChIKey | LVHBHZANLOWSRM-UHFFFAOYSA-N |
Itaconic acid is an endogenous, macrophage-specific immunometabolite that acts as a key mediator of cellular immunometabolism and inflammatory signaling pathways. It directly inhibits succinate dehydrogenase (SDH) and alkylates KEAP1 cysteine residues to promote NRF2 pathway activation, suppressing pro-inflammatory cytokine secretion and reactive oxygen species generation. Through these metabolic and signaling mechanisms, itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 100 mg/mL (超声加热五分钟) |
| DMSO |
26 mg/mL
(199.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 26 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.