CAS No. 1628870-27-8

Batch: Purity:99.23
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Itacnosertib (TP-0184) Chemical Structure
Chemical Structure
Check the Itacnosertib (TP-0184) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-N-[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-N-(2-pyridin-2-yl-3-pyridinyl)pyrimidine-2,4-diamine
CAS Number 1628870-27-8
Molecular Formula

C26H28N8O
Molecular Weight (MW) 468.55
InChIKey XSQKEVGTZSBVBR-UHFFFAOYSA-N

Ordering Information

Biological Activity

Itacnosertib (TP-0184) is a small-molecule inhibitor of the BMP type 1 receptor ALK2 (ACVR1) and FLT3 kinase. Blockade of ALK2 and FLT3 signaling impairs downstream receptor signaling cascades, suppressing hepcidin gene expression and improving serum iron mobilization. In acute myeloid leukemia models, this target inhibition disrupts cell cycle progression, reduces leukemic cell proliferation, and sensitizes resistant cell populations to apoptotic signaling. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 15 mg/mL (32.01 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.