CAS No. 155270-99-8
| IUPAC Name | 8-[(E)-2-(3,4-dimethoxyphenyl)ethenyl]-1,3-diethyl-7-methylpurine-2,6-dione | |
|---|---|---|
| CAS Number | 155270-99-8 | |
| Molecular Formula |
C20H24N4O4 |
|
| Molecular Weight (MW) | 384.43 | |
| SMILES | CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)C=CC3=CC(=C(C=C3)OC)OC)C | |
| InChIKey | IQVRBWUUXZMOPW-PKNBQFBNSA-N |
Istradefylline is a potent, selective adenosine A2A receptor antagonist. By inhibiting adenosine A2A receptor activity in the striatum, it modulates dopaminergic neurotransmission and downstream basal ganglia signaling pathways. In MPTP-treated parkinsonian marmoset models, oral administration of istradefylline attenuates motor disability in a dose-dependent manner without inducing dyskinesia, highlighting its potential to alleviate parkinsonian motor symptoms. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
6 mg/mL
(15.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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