CAS No. 579-56-6

Batch: Purity:99.89
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Isoxsuprine hydrochloride Chemical Structure
Chemical Structure
Check the Isoxsuprine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 579-56-6
Molecular Formula

C18H24ClNO3
Molecular Weight (MW) 337.84
SMILES CC(COC1=CC=CC=C1)NC(C)C(C2=CC=C(C=C2)O)O.Cl

Biological Activity

Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist that exhibits potent vasodilator activity. Activation of beta-2 adrenergic receptors stimulates adenylate cyclase, leading to increased intracellular cyclic AMP levels and subsequent relaxation of vascular smooth muscle cells. This compound effectively promotes peripheral vasodilation and modulates smooth muscle tone through downstream signaling pathways involving protein kinase A. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 68 mg/mL (201.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 4 mg/mL
Ethanol 4 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] LISH PM, et al. J Pharmacol Exp Ther. 1960;129:438-44.

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Note: Technical data last updated: Sep 1, 2026.